Objectives

To develop highly performing galenic formulations based on the use of sublingually delivered nanomedicines for the improvement of the current chemotherapies employed in CHAGAS disease treatments.

Specific objectives:

·         Novel benznidazole lipid-based drug delivery systems: 1) Solid Lipid Nanoparticles (SLNs), as particulate drug carrier systems able to achieve a sustained release of the drug minimizing its adverse effects, 2) Small Unilamellar Vesicles (SUVs) with tailored size, morphology, supramolecular structure and response to external stimuli, in order to improve the pharmacological properties of the API.

·         Alternative drug administration path: 1) New formulations of the nanostructured API for its sublingual administration to reach directly blood stream in order to avoid hepatic first-pass effect and obtain an optimum concentration.

Task

·         Task 1. Solid Lipid Nanoparticles (SLNs) as drug delivery systems

·         Task 2. Small Unilamellar Vesicles (SUVs) as drug delivery systems

 

·         Task 3. Development of a sublingual formulation suitable for the administration of the drug delivery system